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  • 5-yr PSA

    I had my 5-year PSA and visit. My PSA went up a bit to 0.038; however, it has done so in the past only to come back down. So my uro and I are not very worried. His comment on his practice's patient portal was "Good! Although technically a little higher, it was 0.037 12/2020 and subsequently decreased. We will continue to monitor."

    All my post-RP PSA results are in my signature below.

    Djin
    69 yr at diagnosis, BPH x 20 yr, 9 (!) negative biopsies, PCA3-
    7-05-13 TURP for BPH (90→30 g) path negative for PCa, then 6-mo. checks
    6-06-17 Nodule on right + PSA rise on finasteride: 3.6→4.3
    6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
    Nodule was negative for PCa
    Bone scan, CTs, X-rays: neg.
    8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
    SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
    pT2c pN0 pMX, G9 (4+5) acinar adenocarcinoma
    5% of prostate (4.5 x 5 x 4 cm, 64 g) involved
    Dry; ED OK with sildenafil
    11-10-17 Decipher score: 0.37, Low Risk:
    5-yr met risk: 2.4%, 10-yr PCa-specific mortality: 3.3%
    9-16-17 (5 wk) PSA <0.1
    LabCorp uPSA:
    11-28-17 (3 m ) 0.010
    02-26-18 (6 m ) 0.009
    05-30-18 (9 m ) 0.007 (nadir)
    08-27-18 (1 yr.) 0.018 (?)
    09-26-18 (13 m) 0.013 (retest)
    11-26-18 (15 m) 0.012
    02-25-19 (18 m) 0.015
    05-22-19 (21 m) 0.015
    08-28-19 (2 yr. ) 0.016
    12-18-19 (28 m) 0.015
    06-30-20 (34 m) <0.014
    12-30-20 (40 m) 0.037 (?)
    03-31-21 (43 m) 0.020
    07-13-21(46 m) 0.018
    01-25-22 (52 m) 0.023
    07-25-22 (5 yr) 0.039

  • #2
    I think I'll celebrate it dropping again if you don't mind.
    Age Dx'd 57
    PCa History: Father, Grandfathers
    Oct16 Bx: Gleason 4+3 Grade Group 3 w/PNI
    LB: 4+3 (60% pattern 4),
    RA: 3+3, RLM: 3+3, RLA: 3+3

    Jan 2017 RALP - Pathology = pT3a; Gleason 4+3; Weight: 42g

    Jun 2019 AMS800 installed, Jul 2019 activated - Dr. David Rapp
    Sep 2022 AMS800 failed. Scheduling a replacement if possible.
    PSA_TESTS
    Apr16-5.10
    Jul16-4.70
    Aug16-5.13

    ---Surgery---
    Mar17<0.01
    Jul17<0.01
    Oct17<0.01
    Jan18<0.01
    May18<0.01
    Nov18<0.01
    Jan19<0.01
    Jun19<0.02
    Nov20<0.10
    May21<0.10
    Apr22<0.10

    Comment


    • #3
      I agree. Nothing seems alarming.. How often will your testing be?? And congrats on remission for 5 years.
      Wife posting - DOB 5/76- Black Male

      PSA Hist:
      1/2018 2.66
      1/2019 3.39
      Retest 2/019 3.04

      MRI 3/2019: 3 Lesions identified (1) Pirads 4 & (2)Pirads3
      MRI Guided Biopsy 4/11/2019: G6(3+3)

      RMB: 10% of 1 core
      RMM: 10% of the tissue (fragmented specimen).
      RMA: High-grade prostatic intraepithelial neoplasia.
      RLB: 25% of 1 core.
      RLM: 70% of tissue
      RLA: 50% of 1 core.
      LMB: 80% of 1 core.
      Lesion #2, in 3 of 3 cores, 80% of total tissue

      RALP 6/5/19 USMD Arlington Dr. R. Parham
      Cath 6 days, bladder spasms, cath back in for 5 days
      No incontinence/Minimum ED (using Sildenafil as needed)

      Final Path 6/11/19: G6(3+3)
      SV, BNI, Adipose Tissue, ECE, Margins, PNI, LVI, LNI(0of8) All Negative

      PT2N0 ~10% involved by tumor

      Quest Diagnostics uPSA:
      9/7/19 (3mths) <0.02
      1/4/20 (7mths) <0.1 & <0.02
      1/20/20 Annual physical <0.02
      6/6/20 (1yr) <0.02
      12/5/20(18mths) <0.02
      6/5/21(2Yr) <0.1
      1/17/22(31mths) 0.009-Clinical Path Lab ultrasensitive
      6/9/22(3 years)<0.04


      ​​​​
      ​​​​

      Comment


      • #4
        Originally posted by Honeybun078 View Post
        I agree. Nothing seems alarming.. How often will your testing be?? And congrats on remission for 5 years.
        Thank you!

        When I reached the 3-year mark, my uro said he was comfortable testing every 6 months instead of 3, but that I should choose whatever interval made me comfortable 3, 4 or 6 (he said that given my high Gleason score, the insurance company wouldn't have a problem with any schedule). I did 4 months for a bit, but after one jump upward we retested after one month and my PSA came back down, so the fluctuations don't bother me. I'll probably stay on a 6-month schedule, but may check it in 3; however, this would be more curiosity than concern. It my next PSA comes down, I'll stay with 6 months. If it goes up, depending on how much, I might go to 3.



        Djin



        69 yr at diagnosis, BPH x 20 yr, 9 (!) negative biopsies, PCA3-
        7-05-13 TURP for BPH (90→30 g) path negative for PCa, then 6-mo. checks
        6-06-17 Nodule on right + PSA rise on finasteride: 3.6→4.3
        6-28-17 Bx #10: 2/14 cores: G10 (5+5) 50% RB, G9 (4+5) 3% RLM
        Nodule was negative for PCa
        Bone scan, CTs, X-rays: neg.
        8-7-17 Open RP, negative frozen sections, Duke Regional Hosp.
        SM EPE BNI LVI SVI LNI(5L, 11R): negative, PNI+, nerves spared
        pT2c pN0 pMX, G9 (4+5) acinar adenocarcinoma
        5% of prostate (4.5 x 5 x 4 cm, 64 g) involved
        Dry; ED OK with sildenafil
        11-10-17 Decipher score: 0.37, Low Risk:
        5-yr met risk: 2.4%, 10-yr PCa-specific mortality: 3.3%
        9-16-17 (5 wk) PSA <0.1
        LabCorp uPSA:
        11-28-17 (3 m ) 0.010
        02-26-18 (6 m ) 0.009
        05-30-18 (9 m ) 0.007 (nadir)
        08-27-18 (1 yr.) 0.018 (?)
        09-26-18 (13 m) 0.013 (retest)
        11-26-18 (15 m) 0.012
        02-25-19 (18 m) 0.015
        05-22-19 (21 m) 0.015
        08-28-19 (2 yr. ) 0.016
        12-18-19 (28 m) 0.015
        06-30-20 (34 m) <0.014
        12-30-20 (40 m) 0.037 (?)
        03-31-21 (43 m) 0.020
        07-13-21(46 m) 0.018
        01-25-22 (52 m) 0.023
        07-25-22 (5 yr) 0.039

        Comment


        • #5
          Your testing schedule sounds very thought out and logical. I did every six months, but unfortunately using the standard PSA. I've learned my lesson now...uPSA for me from now on
          BD: 1959 PSA 4.9 11/2012 (no symptoms)
          Biopsy 12/2012 Negative
          PSA 5.9 05/2013 (still no symptoms)
          Biopsy 6/2013 3+4 (thank goodness for PSA tests)
          1 core positive (upper left), 1 suspicious (lower left) out of 12
          DRE: bump right side T1c; PCA-III = 20 (normala)

          Da Vinci 7/18/2013:
          Total prostatectomy with seminal vesicles (S13-6085, 1-29, 7/18/13, 29 H&E and 1 paraffin block)
          Invasive carcinoma involves left lobe of prostate only, extends from left apex to posterior mid region of left lobe Gleason 7/10 (4+3); G4 tumor comprises 75% of invasive carcinoma present
          Estimated total volume of carcinoma in entire prostate gland: 10%
          TNM: T2b NX MX (Stage IIA)

          PSA History:
          8/13 11/13 2/14 8/14 2/15 8/15 3/16, 8/16, 3/17,9/17,4/18, 9/18 PSA "undetectable" (PSA <.1)

          March '19 = 0.1
          April '19 = 0.10 <-- switched to uPSA tests
          June '19 = 0.10
          Sept '19 = 0.10
          Dec '19 = 0.09
          Jan '20 = 0.13
          May '20 = 0.2 <- standard test by mistake
          Jun '20 = 0.11 <- back to uPSA test
          Aug '20 = 0.16
          Jan '21 = 0.23
          Feb '21 =0.20
          Mar '21 - started ADT/HT, radiation scheduled
          Jun '21 Eight Weeks Radiation @MSKCC
          Jul '21 <.05 (T-Level 0)
          Feb '22 <.05 (T-Level back to normal)
          Aug '22 <.05 (T-Level still normal)

          Comment


          • #6
            Djin,

            Huge congratz on your 5-year anniversary! Keep up the great work!

            IndyGuy
            DOB: 10/1962

            6-01-15 PSA 2.5
            Having urination flow issue in first half of 2018
            6/25/18 PSA 14.25; Cipro 14 days
            8/1/18 PSA 17.44; rec. Urologist appt
            8/15/19 First Uro appt. + for bacteria. Cipro 4 weeks
            10/2/19 PSA 22.4; Still + for bacteria. Antibiotics 4wks
            12/28/19 PSA 27.5
            1/15/20 Biopsy results 6/12 cores positive - all left side; GS 4+3
            1/18/19 Bone scan and CT scan both negative
            2/15/19 Di Vinci RP
            2/18/19 Path report pT3a, GS 4+3 (60%+35%) 5% GS5, SM +, EPE +; LVI -, SVI -, LNI(9) - ; Tumor size: 3.5cmx3.5cmx1.5cm; single foci left side; right side nerves spared; SM+ at apex limited <1mm; benign prostatic cells at spared right nerve bundle. Prostate size 45gm. Cath out at 7 days: 100% continent.
            Decipher 0.73
            9/26-11/19/19 eSRT (70.2 Gy)

            PSA Test Results
            03/26/19 (6 weeks) 0.033
            05/10/19 (3 months) 0.010
            08/02/19 (6 months) 0.019
            08/30/19 (7 months) 0.024
            12/12/19 (10 months) 0.012
            06/09/20 (16 months) <0.008
            11/13/20 (21 months) 0.010
            02/23/21 (24 months) 0.020
            05/24/21 (27 months) 0.020
            08/16/21 (30 months) 0.020
            01/26/22 (36 months) 0.020
            08/17/22 (42 months) 0.050
            09/15/22 (43 months) 0.060

            Comment

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